SILENCE THERAPEUTICS PLC
SILENCE THERAPEUTICS PLC is a Public Limited Company registered in United Kingdom under 02992058, and its current status with Companies House is active. The company was incorporated on 18 November 1994 and lists its registered address as London, United Kingdom. 5 shareholders are on record for SILENCE THERAPEUTICS PLC, including at least one natural person recorded as a direct holder; the filing carries no beneficial-ownership flag, so that holder is noted here as a recorded shareholder rather than a confirmed ultimate beneficial owner (UBO). This profile is sourced directly from Companies House and was last updated on 22 September 2026.
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Shareholders
5
Shareholders of SILENCE THERAPEUTICS PLC
Five shareholders are currently on record for SILENCE THERAPEUTICS PLC, held on the Confirmation Statement (CS01), filed under the Companies Act 2006. The largest of these is RICHARD GRIFFITHS FLOOR 1 LIBERATION STATION ESPLANADE ST, holding 41% — the largest recorded stake — followed by TCG CROSSOVER MANAGEMENT, LLC 705 HIGH STREET PALO ALTO at 10.5%; the remaining 3 shareholders shown hold smaller stakes. 3 shareholders shown are companies, so the ownership chain continues above this level for those holdings; the other 2 are recorded as direct individual holders, though the record carries no UBO/PSC flag confirming beneficial-owner status.
Data availability
The register reports 11 shareholders in total, though only the top 5 by holding are shown in this view.
| Shareholder | Type | Holding | Source Document |
|---|---|---|---|
| RICHARD GRIFFITHS FLOOR 1 LIBERATION STATION ESPLANADE ST | 41% | Companies House | |
| TCG CROSSOVER MANAGEMENT, LLC 705 HIGH STREET PALO ALTO | 10.5% | Companies House | |
| INVUS PUBLIC EQUITY ADVISORS, LLC 750 LEXINGTON AVENUE, | 9.7% | Companies House | |
| Morgan Stanley | 1.4% | Companies House | |
| -SSgA SPDR ETFS Europe I-SPDR MSCI Europe Small Cap UCITS ETF | 0% | Companies House |
Officers
5
Directors and officers of SILENCE THERAPEUTICS PLC
One of the 5 officer records shown for SILENCE THERAPEUTICS PLC is a current appointment, filed with Companies House. Dave Lemus (appointed 2018-06-21) serves as Director. The remaining 4 records shown (Graham Rook, Iain Rugheimer and 2 others) are former appointments that have since been resigned. Management authority at SILENCE THERAPEUTICS PLC sits with these individuals, not with shareholders, who are covered separately and hold ownership rather than control. The source filing doesn't specify representation authority — whether officers can act individually or must sign jointly to bind the company — so that detail isn't available here.
Data availability
The register reports 52 officers in total, including past appointments, though only the 5 most relevant records are shown here.
Group Structure
Group structure of SILENCE THERAPEUTICS PLC
SILENCE THERAPEUTICS PLC has no recorded parent company — it sits at the top of its own group structure, with 6 subsidiaries recorded beneath it across 3 jurisdictions. Each of these downward relationships is derived rather than filed: resolved by matching entities across the registry network, not stated directly in a single document.
- SILENCE THERAPEUTICS (LONDON) LIMITED (United Kingdom)
- Silence Therapeutics, Inc. (United States)
- Intradigm Corporation (United States)
- INNOPEG LIMITED (United Kingdom)
- Silence Therapeutics GmbH (Germany)
- Silence Therapeutics, Inc. (United States)
Data availability
Those 6 subsidiaries span United Kingdom, United States, Germany jurisdictions, though this list should not be read as complete — subsidiaries only become visible here where shareholder data has actually been filed with a register, so holdings in jurisdictions without that filing simply won't appear.
SILENCE THERAPEUTICS PLC
United Kingdom
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Frequently Asked Questions
Who owns SILENCE THERAPEUTICS PLC?
Five shareholders are currently on record for SILENCE THERAPEUTICS PLC, held on the Confirmation Statement (CS01), filed under the Companies Act 2006. The largest of these is RICHARD GRIFFITHS FLOOR 1 LIBERATION STATION ESPLANADE ST, holding 41% — the largest recorded stake — followed by TCG CROSSOVER MANAGEMENT, LLC 705 HIGH STREET PALO ALTO at 10.5%; the remaining 3 shareholders shown hold smaller stakes. 3 shareholders shown are companies, so the ownership chain continues above this level for those holdings; the other 2 are recorded as direct individual holders, though the record carries no UBO/PSC flag confirming beneficial-owner status.
Who is SILENCE THERAPEUTICS PLC's UBO (Ultimate Beneficial Owner)?
At least one shareholder recorded for SILENCE THERAPEUTICS PLC is a natural person. The record carries no dedicated UBO/PSC flag, so that holder is stated here as a recorded shareholder rather than a confirmed Ultimate Beneficial Owner (UBO).
How many shareholders does SILENCE THERAPEUTICS PLC have on record?
5 shareholders are shown on record for SILENCE THERAPEUTICS PLC. The register reports 11 in total; only the top 5 by holding are shown here.
What is SILENCE THERAPEUTICS PLC's company registration number?
SILENCE THERAPEUTICS PLC's registration number is 02992058, filed with Companies House in United Kingdom. Its current status on the register is active.
Is SILENCE THERAPEUTICS PLC still an active company?
SILENCE THERAPEUTICS PLC's status on Companies House is listed as active.
When was SILENCE THERAPEUTICS PLC incorporated?
SILENCE THERAPEUTICS PLC was incorporated on 18 November 1994, according to Companies House.
What is SILENCE THERAPEUTICS PLC's registered address?
The registered address on file for SILENCE THERAPEUTICS PLC is London, United Kingdom.
What legal structure is SILENCE THERAPEUTICS PLC registered as?
SILENCE THERAPEUTICS PLC is registered as a Public Limited Company in United Kingdom.
Who are the officers/directors of SILENCE THERAPEUTICS PLC?
One of the 5 officer records shown for SILENCE THERAPEUTICS PLC is a current appointment, filed with Companies House. Dave Lemus (appointed 2018-06-21) serves as Director. The remaining 4 records shown (Graham Rook, Iain Rugheimer and 2 others) are former appointments that have since been resigned. Management authority at SILENCE THERAPEUTICS PLC sits with these individuals, not with shareholders, who are covered separately and hold ownership rather than control.
Does SILENCE THERAPEUTICS PLC have a parent company or subsidiaries?
SILENCE THERAPEUTICS PLC has no recorded parent company — it sits at the top of its own group structure, with 6 subsidiaries recorded beneath it across 3 jurisdictions. Those 6 subsidiaries span United Kingdom, United States, Germany jurisdictions, though this list should not be read as complete — subsidiaries only become visible here where shareholder data has actually been filed with a register, so holdings in jurisdictions without that filing simply won't appear.
Can Zavia monitor changes to SILENCE THERAPEUTICS PLC's ownership over time?
This profile reflects a point-in-time snapshot from Companies House. Zavia's monitoring API can track changes to SILENCE THERAPEUTICS PLC's registered shareholders, officers, and group structure going forward, flagging updates as they're filed rather than requiring a manual recheck.
Can I access SILENCE THERAPEUTICS PLC's data through an API?
Yes. Zavia's API connects directly to official government ownership registries across 195 countries and territories, including United Kingdom, so records like SILENCE THERAPEUTICS PLC's registration, shareholder, UBO, and group-structure data can be queried programmatically instead of viewed one page at a time.
Where does this company information come from, and how current is it?
This record is sourced directly from Companies House and was last synced on 22 September 2026.